Growth factors from murine sarcoma virus-transformed cells.
نویسندگان
چکیده
منابع مشابه
Growth factors produced by sarcoma virus-transformed cells.
A hypothesis is presented that states that tumor viruses produce their transforming action on cells, at least in part, by the production of endogenous polypeptide growthstimulatory factors. Cells transformed by murine sarcoma viruses have been found to have reduced or absent cell surface receptors for epidermal growth factor (EGF), as compared to the untransformed parental cells and to cells tr...
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A hypothesis is presented that states that tumor viruses produce their transforming action on cells, at least in part, by the production of endogenous polypeptide growthstimulatory factors. Cells transformed by murine sarcoma viruses have been found to have reduced or absent cell surface receptors for epidermal growth factor (EGF), as compared to the untransformed parental cells and to cells tr...
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Cellular transformation of normal rat kidney (NRK) cells by simian sarcoma virus (SSV) results in a complete loss of the cellular requirement of externally added polypeptide growth factors for proliferation. Moreover, SSV-transformed NRK cells have a strongly reduced ability to bind both external platelet-derived growth factor and epidermal growth factor, when compared to nontransformed NRK cel...
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Tumorigenic and nontumorigenic mutants induced by a single 5'-bromodeoxyuridine (BrdU) treatment of a nonproducer (NP) tumorigenic cell line were isolated and characterized. Among the cloned derivatives were examples of virus-free and sarcoma virus-producing cell lines. Oncogenicity did not correlate with production of virus or ease of rescue of the sarcoma genome. All lines, including nononcog...
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We have isolated a strongly mitogenic, type B transforming growth factor (BTGF) released by SnyderTheilen feline sarcoma virus-transformed rat embryo (FeSV-Fre) cells that induces phenotypic transformation of normal NRK cells when they are concomitantly stimulated by analogues of epidermal growth factor (EGF). Molecule filtration chromatography separates BTGF from an EGF-like TGF (eTGF) which i...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1978
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.75.8.4001